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With clinical trials in sight, ResVita Bio reaches out to Netherton Syndrome community

In preparation for future tests of their flagship therapy, the company is offering updates to those afflicted with the disease. Read post

Azalea Therapeutics Presents New Preclinical Data Demonstrating Robust In Vivo Generation of TRAC-CAR T Cells Using Enveloped Delivery Vehicles

Azalea’s dual-vector platform combines T cell-targeted EDVs delivering Cas9 RNP complexes with a human T cell-tropic AAV carrying a promoterless CAR template. This approach enables precise genomic insertion at the TRAC locus, bringing CAR expression under the control of the native T cell receptor promoter. In vivo TRAC insertion is designed to improve potency, persistence and safety by achieving regulated, physiologic CAR expression rather than continuous signaling from exogenous promoters. Read post
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Hermes Biosciences Raises Seed Funding to Make Extracellular Vesicles a Practical Tool for Precision Medicine

Hermes Biosciences, a life science tools company developing a benchtop, hands-off system for the isolation of extracellular vesicles (EVs), today announced it raised a Seed financing round to deliver its first commercial instrument in 2026, aimed at clinical researchers across academia, Pharma, and clinical customers who require standardized, scalable workflows. The round was led by Genoa Ventures, with participation from Paladin Capital Group and Vertical Venture Partners. Pre-Seed capital and company formation support were also provided by Genoa’s venture studio, General Inception. Read post
Profluent CEO Ali Madani photographed in the QB3 office.

East Bay AI biotech company raises $106 million from Jeff Bezos and others

Profluent Bio, a three-year-old Emeryville company, was the first to show that large language models can generate functional proteins. It went on to design the first CRISPR genome-editing system from scratch, creating an open-source gene editor known as OpenCRISPR-1. With its new-found cash from Altimeter and Bezos Expeditions, it now hopes to continue applying its genome editors into antibodies, enzymes and immune system-triggering antigens. It already has cut deals with a handful of partners, such as life sciences tools company Revvity Inc. (NYSE: RVTY) — the former PerkinsElmer Inc. — agricultural player Corteva Inc. (NYSE: CTVA) and the Rett Syndrome Research Trust, to make custom proteins. Read post

Profluent Raises $106M to Scale Frontier AI Models for Programmable Biology

Profluent, a leader in frontier AI for protein design, today announced a $106 million financing co-led by Altimeter Capital and Bezos Expeditions, with participation from existing investors including Spark Capital, Insight Partners, and Air Street Capital. This round brings Profluent’s total funding to $150 million and will accelerate its mission to make biology programmable – transforming how therapeutics, diagnostics, agriculture, and biomanufacturing solutions are developed. Read post
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New in vivo gene editing biotech blossoms from CRISPR pioneer Jennifer Doudna’s lab with $82M

A new West Coast biotech has emerged into the busy in vivo cell therapy space, this time with the backing of Nobel Prize-winning CRISPR pioneer Jennifer Doudna, Ph.D. Azalea Therapeutics has bloomed with $82 million in funding and a dual-vector approach that the company hopes can enable permanent genome editing with a single dose. The funding total includes a $65 million series A that was led by Third Rock Ventures, with RA Capital Management, Yosemite and Sozo Ventures joining the financing bouquet. Read post
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Jennifer Doudna spinoff aims to turn patients’ immune cells into CAR-T fighters with single shot

A spinout from the lab of Nobel laureate Jennifer Doudna has raised $82 million to create drugs that, with a single infusion, can turn patients’ immune cells into cancer- and autoimmune disease-fighting drones. It’s the latest entrant in a high-stakes race to develop what’s known scientifically as in vivo CAR-T treatments. Today’s CAR-T therapies are highly effective at treating certain blood cancers, but patients’ cells have to be removed, reengineered in a facility, and then reinfused — a toxic, expensive, and cumbersome process. Investors and pharma companies are spending billions to create alternatives that transform patients’ cells in their body. Read post
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